研究実績

2019年

  • Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

    Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T.

    Cell Metabolism 2019 Aug 6; 30(2):374-384.e6. doi: 10.1016/j.cmet.2019.05.007.

  • Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy

    Shibata S, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H.

    Front Neural Circuits.2019 May 8; 13:29. doi: 10.3389/fncir.2019.00029.

  • Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing

    Supakul S, Yao K, Ochi H, Shimada T, Hashimoto K, Sunamura S, Mabuchi Y, Tanaka M, Akazawa C, Nakamura T, Okawa A, Takeda S, Sato S.

    Int J Mol Sci.2019 Mar 2; 20(5). pii: E1079. doi: 10.3390/ijms20051079.

  • 2018年

    • Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

      Hashimoto K, Ochi H, Sunamura S, Kosaka N, Mabuchi Y, Fukuda T, Yao K, Kanda H, Ae K, Okawa A, Akazawa C, Ochiya T, Futakuchi M, Takeda S, Sato S.

      Proc Natl Acad Sci U S A.2018 Feb 27; 115(9):2204-2209 doi: 10.1073/pnas.1717363115.

    • Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro

      Ishii K, Sakurai H, Suzuki N, Mabuchi Y, Sekiya I, Sekiguchi K, Akazawa C.

      Stem Cell Reports.2018 Jan; Published online: January 11, 2018. doi: http://dx.doi.org/10.1016/j.stemcr.2017.12.013

      • Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage

      Yusuke Ogata, Yo Mabuchi, Kosuke Shinoda, Yuta Horiike, Mitsuru Mizuno, Koji Otabe, Eriko Grace Suto, Nobuharu Suzuki, Ichiro Sekiya, Akazawa C.

      Regenerative Therapy.2018 Jan; 8, 20–28 doi: org/10.1016/j.reth.2017.12.001

      • 2017年

      • Differentiation of Oligodendrocyte Precursor Cells from Sox10-Venus Mice to Oligodendrocytes and Astrocytes

        Nobuharu Suzuki, Kaori Sekimoto, Chikako Hayashi, Yo Mabuchi, Tetsuya Nakamura, Akazawa C.

        Scientific Reports.2017 Oct; 7, Article number: 14133. doi: 10.1038/s41598-017-14207-0

      • Sensory innervation of the anal canal and anorectal line in Hirschsprung’s disease: histological evidence from mouse models.

        Takeda M, Miyahara K, Akazawa C, Lane GJ, Yamataka A.

        Pediatr Surg Int.2017 Aug;33(8):883-886. doi: 10.1007/s00383-017-4112-5.

      • Prospective isolated mesenchyme stem/stromal cells are enriched in the CD73+ -population and exhibit efficacy after transplantation.

        Suto EG, Mabuchi Y, Suzuki N, Suzuki K, Ogata Y, Taguchi M, Muneta T, Sekiya I,Akazawa C.

        Scientific Reports.2017 Jul;7(1):4838. doi: 10.1038/s41598-017-05099-1.

      • Technical advantage of recombinant collagenase for isolation of muscle stem cells.

        Ishii K, Suzuki N, Mabuchi Y, Sekiya I, Akazawa C.

        Regenerative Therapy.2017 vol.7 1-7;95(2):206-14 doi: http://dx.doi.org/10.1016/j.reth.2017.06.001

      • Isolation of dental pulp stem cells with high osteogenic potential.

        Yasui T, Mabuchi Y, Morikawa S, Onizawa K, Akazawa C, Nakagawa T, Okano H and Matsuzaki Y.

        Inflammation and Regeneration.2017 Apr;;37:8 DOI: 10.1186/s41232-017-0039-4

        • 2016年

        • Semaphorin 3A expression following intestinal ischemia/reperfusion injury in Sox10-Venus mice.

          Takeda M, Miyahara K, Okawada M,Akazawa C, Lane GJ, Yamataka A.

          Pediatr Surg Int.2017 Mar;;33(3):383-388. doi: 10.1007/s00383-016-4039-2.

        • Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc Expression.

          Sato Y, Mabuchi Y, Miyamoto K, Araki D, Niibe K, Houlihan DD, Morikawa S, Nakagawa T, Nakajima T, Akazawa C, Hori S, Okano H, Matsuzaki Y.

          PLoS One.2016 Nov;11(11):e0165946. doi: 10.1371/journal.pone.0165946.

        • Altered differentiation of enteric neural crest-derived cells from endothelin receptor-B null mouse model of Hirschsprung’s disease.

          Fujiwara N, Miyahara K, Nakazawa-Tanaka N, Akazawa C, Yamataka A.

          Pediatr Surg Int. 2016 Sep;24(6):1061-70. doi: 10.1007/s00383-016-3964-4.

        • Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats.

          Ozeki N, Muneta T, Koga H, Nakagawa Y, Mizuno M, Tsuji K, Mabuchi Y, Akazawa C, Kobayashi E, Matsumoto K, Futamura K, Saito T, Sekiya I.

          Osteoarthritis Cartilage.2016 Jun;24(6):1061-70. doi: 10.1016/j.joca.2015.12.018.

        • Purified Human Dental Pulp Stem Cells Promote Osteogenic Regeneration.

          Yasui T, Mabuchi Y, Toriumi H, Ebine T, Niibe K, Houlihan D.D, Morikawa S, Onizawa K, Kawana H, Akazawa C, Suzuki N, Nakagawa T, Okano H, Matsuzaki Y.

          J Dent Res.2016 Feb;95(2):206-14 doi: 10.1177/0022034515610748.

        • Three- and four-dimensional analysis of altered behavior of enteric neural crest derived cells in the Hirschsprung’s disease mouse model.

          Nakazawa-Tanaka N, Miyahara K, Fujiwara N, Urao M, Akazawa C, Yamataka A.

          Pediatr Surg Int.2016 Jan;32(1):3-7. doi: 10.1007/s00383-015-3806-9.

          • 2015年

          • Purified human synovium mesenchymal stem cells as a good resource for cartilage regeneration.

            Ogata Y, Mabuchi Y, Yoshida M, Suto EG, Suzuki N, Muneta T, Sekiya I, and Akazawa C.

            Plos One.2015 Jun 8; 10(6):e0129096. doi: 10.1371/journal.pone.0129096.

          • Suppressive Function of Teneurin-4 in Proliferation and Differentiation of Muscle Satellite Cells for Tissue Regeneration.

            Ishii K, Suzuki N, Mabuchi Y, Ito N, Fukada S, Okano H, Takeda S, and Akazawa C.

            Stem Cells.2015Oct; 33(10):3017-27. doi: 10.1002/stem.2058.

          • Additive dominant effect of a SOX10 mutation underlies a complex phenotype of PCWH.

            Ito Y, Inoue N, Inoue YU, Nakamura S, Matsuda Y, Inagaki M, Ohkubo T, Asami J, Terakawa YW, Kohsaka S, Goto Y,　Akazawa C Inoue T, and Inoue K.

            Neurobiol Dis.2015 Aug; 80:1-14. doi: 10.1016/j.nbd.2015.04.013.

          • Synovial mesenchymal stem cells promote meniscus regeneration augmented by an autologous achilles tendon graft in a rat partial meniscus defect model.

            Ozeki N, Muneta T, Matsuta S, Koga H, Nakagawa Y, Mizuno M, Tsuji K, Mabuchi Y, Akazawa C, Kobayashi E, Saito T, Sekiya I.

            Stem Cells.2015 Jun;33(6):1927-38. doi:10.1002/stem.2030. PubMed

          • High capacity of purified mesenchymal stem cells for cartilage regeneration.

            Suto EG, Mabuchi Y, Suzuki N, Koyanagi A, Kawabata Y, Ogata Y, Ozeki Y, Muneta Y, Sekiya I, Akazawa C.

            Inflammation and RegenerationMar:34(2):78-85. Inflammation and Regeneration

          2014年

          • RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking.

            Lin X, Yang T, Wang S, Wang Z, Yun Y, Sun L, Zhou Y, Xu X, Akazawa C, Hong W, and Wang T.

            Sci Rep.2014 Dec 2;4:7282. doi: 10.1038/srep07282.

          • Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation.

            Suzuki N, Mizuniwa C, Ishii K, Nakagawa Y, Tsuji K, Muneta T, Sekiya I, and Akazawa C.

            J Orthop Res.2014 Jul;32(7):915-22. doi: 10.1002/jor.22616.

          • Abnormal neural crest innervation in Sox10-Venus mice with all-trans retinoic acid-induced anorectal malformations.

            Suzuki R, Miyahara K, Murakami H, Doi T, Lane GJ, Mabuchi Y, Suzuki N, Yamataka A, and Akazawa C.

            Pediatr Surg Int.2014 Feb;30(2):189-95. doi: 10.1007/s00383-013-3452-z.

          • Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.

            Suzuki N, Numakawa T, Chou J, de Vega S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi H, Arikawa-Hirasawa E, Yamada Y, and Akazawa C.

            FASEB J.2014 Mar;28(3):1386-97. doi: 10.1096/fj.13-241034.

          2013年

          • LNGFR(+)THY-1(+)VCAM-1(hi+) cells reveal functionally distinct subpopulations in mesenchymal stem cells.

            Mabuchi Y, Morikawa S, Harada S, Niibe K, Suzuki S, Renault-Mihara F, Houlihan DD, Akazawa C, Okano H, and Matsuzaki Y.

            Stem Cell Reports.2013 Jul 11;1(2):152-65. doi: 10.1016/j.stemcr.2013.06.001.

          • Laminin-1 promotes enteric nervous system development in mouse embryo.

            Nakazawa N, Miyahara K, Okawada M, Yamataka A, Suzuki R, Akazawa C, Tomikawa-Ichikawa N, and Arikawa-Hirasawa E.

            Pediatr Surg Int.2013 Nov;29(11):1205-8. doi: 10.1007/s00383-013-3388-3.

          • Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.

            Sato H, Shibata M, Shimizu T, Shibata S, Toriumi H, Ebine T, Kuroi T, Iwashita T, Funakubo M, Kayama Y, Akazawa C, Wajima K, Nakagawa T, Okano H, and Suzuki N.

            Neuroscience.2013 Sep 17;248:345-58. doi: 10.1016/j.neuroscience.2013.06.010.

          • Prospective isolation of murine and human bone marrow mesenchymal stem cells based on surface markers.

            Mabuchi Y, Houlihan DD, Akazawa C, Okano H, and Matsuzaki Y.

            Stem Cells Int.2013;2013:507301. doi: 10.1155/2013/507301.

          • SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis.

            Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima AM, Akazawa C, Watabe Y, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, and Tsuda H.

            Mod Pathol. 2013 Aug;26(8):1041-50. doi: 10.1038/modpathol.2013.54.

          • Correlation between multiple RET mutations and severity of Hirschsprung’s disease.

            Ishii K, Doi T, Inoue K, Okawada M, Lane GJ, Yamataka A, and Akazawa C.

            Pediatr Surg Int.2013 Feb;29(2):157-63. doi: 10.1007/s00383-012-3196-1.

          • Anorectal neural crest derived cell behavior after the migration of vagal neural crest derived cells is surgically disrupted: implications for the etiology of Hirschsprung’s disease.

            Miyahara K, Kato Y, Suzuki R, Akazawa C, Tanaka N, Koga H, Doi T, Lane GJ, and Yamataka A.

            Pediatr Surg Int.2013 Jan;29(1):9-12. doi: 10.1007/s00383-012-3201-8.

          2012年

          • Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS.

            Suzuki N, Fukushi M, Kosaki K, Doyle AD, de Vega S, Yoshizaki K, Akazawa C, Arikawa-Hirasawa E, and Yamada Y.

            J Neurosci.2012 Aug 22;32(34):11586-99. doi: 10.1523/JNEUROSCI.2045-11.2012.

          • Bioluminescent system for dynamic imaging of cell and animal behavior.

            Hara-Miyauchi C, Tsuji O, Hanyu A, Okada S, Yasuda A, Fukano T, Akazawa C, Nakamura M, Imamura T, Matsuzaki Y, Okano HJ, Miyawaki A, and Okano H.

            Biochem Biophys Res Commun.2012 Mar 9;419(2):188-93. doi: 10.1016/j.bbrc.2012.01.141.

          2011年

          • Visualization of enteric neural crest cell migration in SOX10 transgenic mouse using time-lapse fluorescence imaging.

            Miyahara K, Kato Y, Koga H, Dizon R, Lane GJ, Suzuki R, Akazawa C, and Yamataka A.

            J Pediatr Surg.2011 Dec;46(12):2305-8. doi: 10.1016/j.jpedsurg.2011.09.020.

          • The dual origin of the peripheral olfactory system: placode and neural crest.

            Katoh H, Shibata S, Fukuda K, Sato M, Satoh E, Nagoshi N, Minematsu T, Matsuzaki Y, Akazawa C, Toyama Y, Nakamura M, and Okano H.

            Mol Brain.2011 Sep 23;4:34. doi: 10.1186/1756-6606-4-34.

          2010年

          • Abnormal enteric innervation identified without histopathologic staining in aganglionic colorectum from a mouse model of Hirschsprung’s disease.

            Miyahara K, Kato Y, Koga H, Lane GJ, Inoue T, Akazawa C, and Yamataka A.

            J Pediatr Surg.2010 Dec;45(12):2403-7. doi: 10.1016/j.jpedsurg.2010.08.039.

          • Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes.

            Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, and Okano H.

            Mol Brain.2011 Oct 31;3:31. doi: 10.1186/1756-6606-3-31.